口腔微生物组在口腔精准医疗中的运用
Oral microbiome in the precision medicine
作者：徐欣, 何金枝, 周学东
Author：Xu Xin, He Jinzhi, Zhou Xuedong.
收稿日期：2017-06-09 年卷（期）页码：2017,44(6):619-627
期刊名称：国际口腔医学杂志
Journal Name：International Journal of Stomatology
关键字：口腔微生物组,精准医疗,组学研究,精准预警,精准诊断,精准治疗,精准疗效评估,
Key words：oral microbiome,precision medicine,omics,precise risk prediction,precise diagnosis,precise therapy,precise evaluation,
基金项目：国家自然科学基金（81670978,81600874）; 四川省科技厅重大前沿项目（2016JY0006）; 四川大学华西口腔医院临床新技术项目（LCXJS2015-3）
中文摘要
现代医学已从“以疾病为导向”转至“以患者为导向”,开启了以个体化医疗为目标的精准医疗时代。人体的生理功能不但由自身基因组决定,还受共生菌群即人类微生物组的塑造与影响。目前,人类微生物组的研究已经超越了简单解析组成成员与疾病之间的相关性,开始深入分析其对复杂疾病发病、诊断及治疗的贡献,这些突破性研究成果有望成为推动个性化精准医疗的重要助力。本文着重介绍口腔微生物组的最新研究进展、口腔微生物组在疾病早期风险预警、早期诊断、治疗及疗效评估等方面的探索性运用,讨论了口腔微生物组在精准医疗发展中的潜力,以及整合口腔微生物组信息,实现精准医疗所面临的重大挑战。
英文摘要
Modern medicine has shifted from “disease oriented” to “patient oriented” and has consequently created a new era of personalized medicine or precision medicine. The physiological functions of the human body are determined not only by the human genome but also by symbiotic microflora. Currently, studies on the human microbiome have extended from a simple analysis of the association of bacteria and diseases to a complex analysis of the role of microbiome in the pathogenesis, diagnosis, and treatment of diseases. These breakthroughs possibly promote the practice of personalized/precision medicine. This review summarizes the advances in oral microbiome-related research. In particular, the potential role of oral microbiome in the risk prediction, diagnosis, treatment evaluation, and prognosis of diseases is extensively discussed. Current challenges in the development of oral microbiome-based precision medicine are also described.
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