The cone beam computed tomography(CBCT) has been widely applied in the implantology for its accuracy and reliability in measuring oral anatomical hard tissue. The complications such as nerve damage, bleeding even lifethreatening hemorrhages may occur during the placement of implants in the mandibular interforaminal region. However, the use of CBCT in planning the implant treatments improves the safety and accuracy of such surgeries. Here is to review the relevant issues on the application of CBCT in mandibular interforaminal region.