The vascular endothelial growth factor(VEGF) as an endothelial cell-specific growth factor is one of the most important factors in the formation of new blood vessels. The level of expression of VEGF in some pathological conditions, such as inflammation and tumors, changes significantly to regulate angiogenesis and thus affects the development of the disease. Periodontal disease is a chronic inflammatory disease accompanied by changes in the expression of VEGF, which reveals the changes in the status of the disease to a certain extent. The expression of VEGF in periodontal inflammation increases the degree of inflammation and adjusts the formation of periodontal bone tissues in the repair phase. VEGF can interact with a variety of cytokines during the up-regulation of the VEGF function. VEGF in periodontal tissues and its effect are reviewed in this study.
