Objective This paper adopts the visual analogue scale(VAS) to discuss the influence of psychological interventions on orthodontic treatment pain experienced by patients of different genders. Methods Patients were randomly divided into five groups: blank, cognitive, music, relaxed, and suggestion groups. The pain perception of patients at different times with different psychological interventions was assessed by using VAS. Results The pain values of the cognitive, music, relaxed, and suggestion groups are lower than those of the blank group. The pain values exhibited no significant statistical difference for the blank, music, relaxed, and suggestion groups between different sexes. The pain values differed between sexes in the cognitive group, with men showing significantly lower values than women. Conclusion Music therapy, relaxation therapy, and suggestion therapy can all effectively alleviate orthodontic treatment pain experienced by patients of different sexes with no statistical difference. Cognitive therapy can effectively alleviate the orthodontic treatment pain in patients of different sexes, with men being more effectively influenced than women.