Objective This study aims to investigate the expression of integrin β1(Itgβ1) in endochondral remodeling of rats and provide experiment basis to the regulation mechanism of the mandibular condylar cartilage. Methods A total of 60 male Sprague-Dawley rats were randomly divided into experimental and control groups. In the experimental group, inclined bite plate was cemented to the upper central incisors of the rats for 1 d. Five rats were executed in each group after 1, 3, 7, 14, 21, and 28 d. The specimens of the bilateral temporomandibular joints were subjected to hematoxylin–eosin staining and immunohistochemistry against Itgβ1. Data were presented as immunohistochemical scores(IHS). Results The IHS of Itgβ1 inthe experimental group was significantly higher than that inthe control group, whereasthe changes were normal. Conclusion Itgβ1 has a crucial function in the reconstruction of the condylar cartilage during mandibular forward positioning.
