Hemorrhagic disease which is harmfulness, high death rate and morbidity has become one of the challenges faced by the clinical medicine. While, the blood supply reconstruction of low hemorrhagic diseases have obvious curative effect. Angiogenesis need a variety of mature vascular growth factors in certain time space and mass concentration under the joint action of normal vasculature to vascular endothelial growth factor(VEGF) expression in precise control of time and space. Under different time the specific environment, mass concentration of the same kind of growth factor is not the same, which plays a different role, such as transforming growth factor-β1, VEGF receptors and hif, etc. In the process of angiogenesis and tissue function reconstruction, the direction of the angiogenesis under the influence of directional migration of endothelial cells and smooth muscle cells, branching morphogenesis and VEGF space gradient height adjustment, which reflects the space distribution features of VEGF expression. The time space of vascular growth factors control needs to establish the quantitative standards of cytokines in the organization, so as to accurately control formation damage tissue blood vessels; So looking for the right transfer system to achieve specific growth factors within the area, and understanding of time and space characteristics of vascular growth factor plays an important role in the construction of new blood vessels. The characteristics of the rational utilization of vascular growth factors will provide more choice for the treatment of vascular disease.
