Objective Thisin vitrostudy aimed to measure the roughness and wearing of polished, glazed, and polished and then reglazed zirconia against human enamel antagonists. Methods Zirconia specimens were divided into the polished, glazed, and polished and then reglazed groups(n=8). Enamel was used as a control. The mesiobuccal cusps of extracted maxillary third molars were standardized and used as antagonists. The surface roughness of all pretest specimens was measured, and the effects of treated zirconia on the wear property of the enamel were evaluated by a wear test. Results Surface roughness increased in the following order: polished zirconia