Autism is a life-long neural, developmental disorder characterized by qualitative abnormalities in social interaction, language and communication, and interests, among others. The current prevalence rate has significantly increased. Autistic patients with special oral disease manifestations require special behavioral guidance and oral treatment options. Moreover, autistic patients can easily be influenced by their family and society. Therefore, dentists should apply certain principles and methods of clinical treatment for autistic patients. This paper reviews the current studies on behavioral guidance and therapy decisions in dental treatment of patients with autism.