Objective A new restorative method for the restoration of one to two missing anterior teeth was explored using zirconia all-ceramic resin-bonded bridges fabricated through computer-aided design and computer-aided manufacturing(CAD/CAM). The short-term clinical performance of the bridges was evaluated. Methods Clinical data were collected, and inclusion, as well as exclusion, criteria were determined. A restoration plan was designed. Tooth preparation and laboratory production were performed. Try-in and bonding were conducted. The performance of the bridges was evaluated during follow-up. Results A total of five anterior zirconia all-ceramic resin-bonded bridges were fabricated through CAD/CAM. The bridges included two zirconia all-ceramic resin-bonded bridges with single-retainer design and three zirconia all-ceramic resin-bonded bridges with two-retainer design. The mean observation time was six months. During follow-up, no discoloration, fracture, loosening, and shedding were detected in the zirconia all-ceramic resin-bonded bridges. All abutments had good marginal integrity, and no marginal discoloration or secondary caries was observed. Five restorations were rated as A grade. Conclusion Zirconia all-ceramic resin-bonded bridges fabricated through CAD/CAM exhibited short-term good restoration effects for patients with one or two missing anterior teeth. However, whether the bonding strength of these bridges could meet the clinical requirement requires further investigation.