骨硬化蛋白对牙骨质形成的影响及其机制
Effect of sclerostin on cementogenesis and its mechanism
作者：陈甜,白丁
Author：Chen Tian, Bai Ding
收稿日期：2015-07-10 年卷（期）页码：2016,43(3):333-337
期刊名称：国际口腔医学杂志
Journal Name：International Journal of Stomatology
关键字：牙骨质,骨硬化蛋白,无翅型小鼠乳房肿瘤病毒整合位点家族-β-连环蛋白-信号转导通路,分子机制,矿化组织,牙骨质,骨硬化蛋白,无翅型小鼠乳房肿瘤病毒整合位点家族-β-连环蛋白-信号转导通路,分子机制,矿化组织,
Key words：cementum,sclerostin,wingless-type mice mammary tumour virus integration site family-β-catenin-signal transduction pathway,molecular mechanism,mineralized tissues,cementum,sclerostin,wingless-type mice mammary tumour virus integration site family-β-catenin-signal transduction pathway,molecular mechanism,mineralized tissues,
基金项目：国家自然科学基金（11172190，81371171）；高等学校博士学科专项科研基金（20130181110013）
中文摘要
骨硬化蛋白是一种含有胱氨酸结的分泌型糖蛋白，可通过骨细胞突触传递至骨表面并作用于周围的成骨细胞，从而降低骨的发生发育速度。其机制在于骨硬化蛋白与无翅型小鼠乳房肿瘤病毒整合位点家族蛋白竞争性地结合辅助受体低密度脂蛋白受体相关蛋白5/6，促进β-连环蛋白磷酸化并降低β-连环蛋白水平，从而抑制成骨细胞的分化及活性。牙骨质为连接牙体和牙周组织间的桥梁，其功能在于维系牙体的稳固和牙周组织的健康。骨硬化蛋白参与并影响牙骨质的发生发育等各种生理性活动，因此进一步深入探讨骨硬化蛋白这一骨形成负性调控因子与牙骨质间的相互作用和机制，将有助于牙骨质相关再生领域的发展。
英文摘要
Sclerostin, a secreted glycoprotein with a C-terminal cysteine knot-like domain protein, is produced by the osteocytes and has anti-anabolic effects on bone formation. Sclerostin is an antagonist of Wnt signaling pathway by binding to low density lipoprotein receptor-related protein-5/6 receptors and prompting the phosphorylation of β-catenin. Cementum is a specialized substance covering the root of a tooth and a dynamic entity within the periodontium sustaining the firmness of the tooth. Sclerostin has been identified during cementogenesis, in which the underlying mechanism is still obscure. On this basis, providing a comprehensive insight into the interactional and reciprocal molecular mechanism between sclerostin and cementum may facilitate cementogenesis-related tooth development and regeneration.
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