舍格伦综合征口干症的研究进展
Research progress on xerostomia of Sjögren syndrome
作者：王璐,李霞
Author：Wang Lu, Li Xia
收稿日期：2015-05-06 年卷（期）页码：2016,43(3):314-317
期刊名称：国际口腔医学杂志
Journal Name：International Journal of Stomatology
关键字：舍格伦综合征,口干症,水通道蛋白,瞬时受体电位香草酸,舒血管肠肽,舍格伦综合征,口干症,水通道蛋白,瞬时受体电位香草酸,舒血管肠肽,
Key words：Sj?gren syndrome,xerostomia,aquaporin,transient receptor potential vanillic,vasoactive intestinal peptide,Sj?gren syndrome,xerostomia,aquaporin,transient receptor potential vanillic,vasoactive intestinal peptide,
基金项目：山西省科技攻关项目（20150313010-3）
中文摘要
舍格伦综合征（SS）属于腺体功能受损性自身免疫性疾病，口干症是其首要症状，发病机制不明，尚无有效的治疗方法。水通道蛋白、瞬时受体电位香草酸和舒血管肠肽与SS口干症发病密切相关，本文就三者与SS间的关系等研究进展作一综述。
英文摘要
Sj?gren syndrome(SS) is a chronic autoimmune disease that occurs because of the impairment of the exocrine gland function. Xerostomia is the first sign of SS, and this symptom indicates the beginning of lesions. As the pathogenesis remains unclear, no complete treatment exists. Recently, the functions of aquaporins, capsaicin receptor, and vasoactive intestinal peptide in the pathogenesis of SS xerostomia have gradually received increasing attention. Therefore, this paper reviews the functions and treatment of these factors in the pathogenesis of SS xerostomia.
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