牙龈卟啉单胞菌及其牙龈蛋白酶K对青少年牙龈健康的影响
Influence of Porphyromonas gingivalis and its gingipain K in healthy gingiva of teenagers
作者：韩志强,柏扬,肖水清,孙菲,何萍
Author：Han Zhiqiang, Bai Yang, Xiao Shuiqing, Sun Fei, He Ping
收稿日期：2016-01-02 年卷（期）页码：2016,43(3):283-287
期刊名称：国际口腔医学杂志
Journal Name：International Journal of Stomatology
关键字：青少年,牙龈卟啉单胞菌,青少年,牙龈卟啉单胞菌,牙龈蛋白酶K,牙龈炎,牙龈蛋白酶K,牙龈炎,
Key words：teenagers,Porphyromonas gingivalis,gingipain K,gingivitis,teenagers,Porphyromonas gingivalis,gingipain K,gingivitis,
基金项目：
中文摘要
目的 分析牙龈卟啉单胞菌（P. gingivalis）及牙龈蛋白酶K（Kgp）对青少年牙龈健康的影响。方法 收集12~17岁青少年牙龈正常组（50例）、牙龈炎症指数Ⅰ级组（25例）和牙龈炎症指数Ⅱ级组（32例）的3组龈沟液标本，应用16S rDNA PCR技术检测各样本中的P. gingivalis及Kgp。3组P. gingivalis和Kgp阳性检出率的比较采用χ2检验；P. gingivalis和Kgp的相对含量与牙龈炎症指数之间的关系采用Spearman相关分析。结果 P. gingivalis在牙龈炎症指数Ⅰ级组的检出率大于牙龈正常组，牙龈炎症指数Ⅱ级组的检出率大于牙龈炎症指数Ⅰ级组和牙龈正常组，牙龈炎症指数Ⅰ级组、Ⅱ级组与牙龈正常组间有明显差异（PPPPP. gingivalis和Kgp的检出率随着牙龈炎症指数的增加而升高。结论 P. gingivalis和Kgp与青少年牙龈健康密切相关。
英文摘要
Objective To explore the relationship ofPorphyromonas gingivalis(P. gingivalis), gingipain K(Kgp) and puberty gingivitis in the subgingival. Methods Subjects(12-to 17-year-old children) included 50, 25, and 32 periodontally healthy, puberty gingivitis indexⅠ, and puberty gingivitis index Ⅱ children, respectively. 16S rDNA PCR was conducted to detectP. gingivalisand Kgp from the samples. Chi-square test was performed to compare the prevalence of Kgp andP. gingivalisin the three groups. Spearman correlation analysis was also employed to evaluate the relationship between the relative quantity of Kgp and periodontal parameters. ResultsP. gingivalisin the puberty gingivitis index Ⅱ group was higher than that in the periodontally healthy group. Puberty gingivitis index Ⅱ was higher than puberty gingivitis index Ⅰ and periodontally healthy groups. Puberty gingivitis index Ⅱ, puberty gingivitis index Ⅱ, and periodontally healthy groups were significantly different from one another(PPPPPP. gingivalisand Kgp detection rates increased in the gingivitis index. Conclusion Kgp andP. gingivalisare closely related to puberty gingivitis in the subgingival.
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