Enterococcus faecalis(E. faecalis) is commonly detected in refractory and chronic periapical periodontal infections and is one of the main pathogenic bacteria in the root canal.Streptococcus mutans(S. mutans) is the main pathogenic bacteria caused by dental caries.E. faecalisandS. mutansvirulence factors of lipoteichoic acid(LTA) can promote cells to secrete inflammatory factor, which leads to inflammation, promotes the absorption of periapical alveolar bone, and contributes to bacterial adhesion on tooth surface and biofilm formation.E. faecalisandS. mutansLTA in pathogenic bacteria is important, but its ultimate function is unclear. Therefore, this study investigates the pathogenic mechanism and molecular structure of LTA to understand the blockage of pathogenic pathway and thus reduce its pathogenicity.
