Root canal treatment is the main therapy of dental pulp diseases and periapical diseases. The success or failure of the treatment largely depends on the quality of root canal preparation. In root canal preparation, an access to the pulp cavity is created and continuous, smooth root canal is established. This process is the initial preparation of root canal and results in clean root canal. Accordingly, root canal instruments can smoothly enter the root canal and instrument fracture can thus be avoided. Special instruments are used to establish smooth canal when necessary. Preliminary preparation instruments for root canal with unique function and good forming capability can be developed rapidly. This paper provides constructive suggestions in treating dental pulp and periapical diseases.