Systemic glucocorticoid therapy has been the main therapy for the treatment of many diseases, including pemphigus vulgaris. However, roughly two-thirds of these patients experience at least one glucocorticoid-induced adverse event. Therefore, understanding the side effects of glucocorticoids and managing them properly is critical for treating pemphigus vulgaris. This paper reviews the adverse events and relevant treatments during glucocorticoid interventions of pemphigus vulgaris.