橙皮素在大鼠体内的吸收机制
Study on the absorption mechanism of hesperetin in rat
作者：周能;冯海珍;宋健娟;
Author：
收稿日期： 年卷（期）页码：2019,34(02):-147-151
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：橙皮素;维拉帕米;血浆浓度;组织分布;高效液相色谱;药动学;吸收机制;P-糖蛋白;外排
Key words：
基金项目：国家自然科学基金资助项目(批准号:81060360);;
广西自然科学基金资助项目(2015GXNSFAA139042);;
广西高校重点科研项目(KY2015ZD100)
中文摘要
目的探讨维拉帕米对橙皮素血浆浓度与肝脏分布的影响,揭示橙皮素的吸收机理。方法将大鼠随机分为3组,第1组灌胃橙皮素的0. 5%羧甲基纤维素钠溶液,第2组灌胃橙皮素和维拉帕米的0. 5%羧甲基纤维素钠溶液,第3组作为对照组,给药后于1、2、4 h三个时间点,取血浆及肝脏,经处理后,用HPLC测定药物的含量。结果维拉帕米+橙皮素组与橙皮素组的血药浓度与肝脏含药量存在显著性差异。结论橙皮素以缀合物被吸收,且以原型在肝脏分布,维拉帕米可显著提高橙皮素的吸收及肝脏分布量。维拉帕米抑制p-糖蛋白从而抑制橙皮素外排是其促进吸收的原因之一。
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