碘催化色酮与吡啶乙酸乙酯[3+2]环化合成结构新颖的中氮茚类化合物
Iodine-catalyzed [3+2] cyclization for the synthesis of structurally novel indolizines with chromones and 2-pyridylacetates
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收稿日期： 年卷（期）页码：2020,35(01):-16-23
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：中氮茚;环加成;色酮;吡啶乙酸乙酯;单质碘;合成;结构新颖;自由基反应
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中文摘要
目的建立简单、绿色、高效合成结构新颖的中氮茚类化合物的方法。方法以色酮和吡啶乙酸乙酯为底物、1,4-二氯苯为溶剂、二叔丁基过氧化物为氧化剂,在单质碘的催化下,制备中氮茚类化合物。结果与讨论发展了一种操作简单、绿色的方法,合成了一系列结构新颖的中氮茚类化合物,产物结构经1HNMR、1HNMR、(13)CNMR、(13)CNMR、(19)FNMR和HR-MS表征。该反应具有底物适用范围广、收率高和条件温和的优点。初步的机理研究表明反应产生了自由基中间体。
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