模板法制备高光热性能的新型氧化钨纳米颗粒及其表征
Preparation of high photothermal properties of W_(18)O_(49) nanoparticles by the template method and its characterization study
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收稿日期： 年卷（期）页码：2020,35(03):-256-260
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：光热治疗;模板法;氧化钨;六氯化钨;介孔二氧化硅;水热法;近红外光;Hela细胞
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中文摘要
目的制备具有较好形貌和光热转换性能的新型氧化钨纳米复合物,并对其进行表征。方法采用模板法制备介孔二氧化硅(mSiO_2)纳米颗粒,将WCl_6吸附进入mSiO_2中,通过高温水热法一步合成有固定形貌的水溶性氧化钨(WO@mSiO_2)纳米颗粒。采用透射电子显微镜和粒度仪分析纳米颗粒的形貌和大小;初步评价WO@mSiO_2的光热转化情况;MTT法初步考察对其对Hela细胞的毒性作用及808 nm近红外光照射后对肿瘤细胞的光热杀伤效果。结果模板法制备的WO@mSiO_2具有较好的分散性,粒径105 nm。经808 nm近红外光照射后,氧化钨纳米颗粒具有较好的光热转化效果。MTT试验结果表明:氧化钨纳米颗粒具有较好的细胞安全性。经808 nm近红外光照射后,对肿瘤细胞具有较高的光热杀伤效率。结论模板法合成的WO@mSiO_2具有较好的光热性能,有用于肿瘤临床治疗的潜能。
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