5-氟尿嘧啶-D-氨基葡萄糖衍生物的设计与合成
Design and synthesis of 5-fluorouracil-D-glucosamine derivatives
作者：杨琴;张志荣;
Author：
收稿日期： 年卷（期）页码：2014,29(04):-359-361
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：D-氨基葡萄糖;5-氟尿嘧啶;衍生物;制备
Key words：
基金项目：
中文摘要
目的设计并合成5-氟尿嘧啶-D-氨基葡萄糖衍生物。方法以D-氨基葡萄糖为起始原料,经保护、水解、酯化、叠氮化、还原等反应,所得中间体与5-氟尿嘧啶-1-乙酸酰化,再脱去保护得目标化合物。结果与结论成功制备了5-氟尿嘧啶-D-氨基葡萄糖衍生物,目标化合物经1HNMR、13CNMR和LC-MS确证。
英文摘要
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