pH敏感药用载体mPEG-HZ-Chol的合成及胶束的制备
Synthesis of pH-sensitive m PEG-HZ-Chol and preparation of self-assembly of paclitaxel polymeric micelles
作者：李红霞;陆燕;张思颖;常月红;
Author：
收稿日期： 年卷（期）页码：2015,30(02):-131-133
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：聚乙二醇;胆固醇;药用载体;pH敏感性;合成;胶束
Key words：
基金项目：江苏省自然科学基金青年基金项目(BK20130526);;
江苏大学学生科研立项(12A486)
中文摘要
目的设计合成p H敏感药用载体材料m PEG2000-HZ-Chol,并考察其p H敏感性。方法以胆固醇为原料,在酯化、酰肼化后,与m PEG醛通过p H敏感的腙键连接,合成目标物并进行p H敏感性的研究。使用红外光谱、核磁共振、薄层色谱等方法对其进行表征,评价其体外p H敏感性。结果与结论所合成的材料具有p H敏感性,p H敏感值为5.5。
英文摘要
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