新型吲哚七甲川菁染料作为光声成像造影剂的初步研究
Primary study of novel heptamethine indocyanine dyes as photoacoustic imaging contrast agents
作者：潘玲;郭丽;罗圣霖;齐庆蓉;
Author：
收稿日期： 年卷（期）页码：2017,32(02):-113-116
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：吲哚七甲川菁;染料;合成;光声成像;信号强度;造影剂
Key words：
基金项目：国家自然科学基金重点资助项目(批准号:81130026)
中文摘要
目的合成末端取代基为甘氨酸甲酯的吲哚七甲川菁染料(PLGAS-1),研究其作为光声成像造影剂的效果。方法 3-溴丙酸经氯代后与甘氨酸甲酯盐酸盐成3-溴丙酰胺甲酯(XBXA-3)后,再与2,3,3-三甲基-3H吲哚反应,制得季铵盐JAY-1,进而与2-氯-3-羟次甲基环己烯醛缩合制得目标化合物PLGAS-1。测定目标物的最大吸收波长、发射波长及通过建立体外仿体模型,对比研究PLGAS-1和吲哚菁绿(ICG)及金纳米棒(CTAB-7-760)的光声信号强度。结果合成并确证了PLGAS-1的化学结构,其最大吸收和发射波长均在近红外区;体外光声成像研究显示:相同实验条件下,PLGAS-1的光声成像信号强度明显高于ICG和CTAB-7-760,且其光声信号强度与浓度有良好的线性关系。结论新型吲哚七甲川菁染料可为新型光声成像造影剂的研究提供思路。
英文摘要
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