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口腔黏膜黏附材料的研究进展

Progress of research on oral mucosal adhesive agents

作者:赵行

Author:Zhao Hang.

收稿日期:2022-09-06          年卷(期)页码:2023,41(1):1-1-10

期刊名称:华西口腔医学杂志

Journal Name:West China Journal of Stomatology

关键字:口腔黏膜,局部给药,黏附,

Key words:oral mucosa,local administration,adhesion,

基金项目:国家自然科学基金(81922020);四川省科技厅项目(2021-YJ-2021)

中文摘要

基于口腔黏膜结构的独特性和给药的方便性,局部药物递送在口腔黏膜疾病的治疗中得到广泛应用。但由于口腔是一个有开放、湿润及运动的特殊微环境,口腔黏膜给药面临着巨大挑战。针对这一困境,近年来黏附材料得以深入研究,以期延长药物局部停留时间,从而达到药物缓释和提高生物利用度的目的,具有广泛的应用前景,本文将针对口腔黏膜黏附材料的特点和现状简要总结。

英文摘要

Oral mucosal administration is extensively used to treat systemic diseases and oral mucosal diseases owing to unique oral mucosal structure and convenient administration. However, the special microenvironment of the oral cavity being open, moving, and humid causes oral mucosal drug delivery to face great challenges. To address this dilemma, local adhesive agents have been widely studied for sustained drug delivery and improved bioavailability, showing broad prospects. Recently, the author has performed studies on oral mucosal adhesive agents. In this paper, the progress of research on oral mucosal adhesive materials is reviewed.

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