A sequencing batch membrane bioreactor with polymer microcarriers was introduced to treat synthetic organic wastewater and industrial wastewater containing toluene and xylene. The removal effect of pollutants and the influence factors of membrane fouling were observed. The results showed that when the synthetic organic wastewater with the influent COD concentration of 218~1003 mg/L and NH3-N concentration of 24~96 mg/Lwas treated , the removal rates of COD and NH3-N were 87%~99% and 65%~99%, respectively; when industrial wastewater with the influent COD concentration of 174~709 mg/L and NH3-N concentration of 18~63 mg/L was treated, the removal rates of COD and NH3-N were 60%~96% and 72%~94%, respectively. It was found that, there was not significant membrane fouling when the MLSS concentration was under 19.28 g/L after polymer microcarriers were put into the MBR. Continuous suction impelled faster growth of transmembrane pressure difference, which accelerated membrane pollution. The operations of sequencing batch MBR with polymer microcarriers were studied, which provided the basis for practical application of this new pattern MBR.