Cleft palate is one of the most prevalent congenital craniofacial birth defects in human. The complexity of the tissues and structures involved in cleft palates poses a significant challenge in stomatology. Current treatments for cleft palate involve well -described surgical techniques. However, surgical intervention has some complications. The application of tissue engineering principles could significantly improve the treatment effect. This review would briefly introduce the application of tissue engineering strategies, with an emphasis on the areas in which tissue engineering could have a significant impact, such as soft and/or hard palate tissue regeneration and alveolar bone regeneration.
