Hard palatal mucoperiosteum flap has merits of manufacturing easily and high survival rate. It can be manufactured pedicle flap with blood vessel, random flap, free flap to repair the defects of soft tissues of oral maxillofacial region, especially to the defects of smaller area on oral soft tissues. This article was an overview of clinical application of hard palatal mucoperiosteum flap, proposing to provide choices to clinical surgical works.