唾液分泌型免疫球蛋白A 对口腔白假丝酵母菌黏附的影响

摘要：目的 从唾液分泌型免疫球蛋白A（sIgA）的质量浓度和白假丝酵母菌黏附率变化的角度探讨人类免疫缺陷病毒（HIV）感染者易感染口腔假丝酵母菌病的原因。 方法 检测唾液sIgA的质量浓度，并通过体外黏附试验观察白假丝酵母菌标准株（SCAL）和临床分离株（CCAL）在含和不含sIgA 环境中与颊上皮细胞的黏附率，比较HIV 感染组与健康对照组口腔内白假丝酵母菌的黏附率。 结果 HIV 感染组sIgA的质量浓度低于健康对照组（P＜0.05）；在含sIgA环境中，SCAL 和CCAL 的黏附率总体均值低于不含sIgA 环境中SCAL 和CCAL 的黏附率总体均值，两组间差异有统计学意义（P=0.001）；在含sIgA 环境中，HIV 感染组口腔中的白假丝酵母菌的黏附率明显高于健康对照组（P＜0.05）。 结论 HIV 感染组易感染口腔假丝酵母菌病与唾液sIgA的质量浓度变化和白假丝酵母菌黏附力改变密切相关。

关键词:分泌型免疫球蛋白A,白假丝酵母菌,黏附,人类免疫缺陷病毒,获得性免疫缺陷综合征

Abstract:Objective To discuss the reason from which oral cavity Saccharomyces albicans get sick for being infected from the angle of looking at the human immunodeficiency virus（HIV）-infected persons and analyzing the saliva secreted immunoglobulin A（sIgA） content and the Saccharomyces albicans adherency change rates. Methods To exam saliva sIgA content, to observe the Saccharomyces albicans standard and clinical separation in content of sIgA that is not contained in the sIgA environment and the buccal mucosa epithelial cell adherency rate by the sticky experiment, and to compare the differences of oral cavity Saccharomyces albicans adherency rate between HIV/acquired immunodeficiency syndrome（AIDS） group and healthy control group. Results The sIgA content in HIV/AIDS group is lower than that of the healthy group（P＜0.05）. In the environment of sIgA content, the ensemble average of Saccharomyces albicans stick rate（standard and clinical separation） is lower than that of the non-sIgA environment, and therefore the differences between the two groups do have the statistics significance（P=0.001）. In the environment of sIgA content, Saccharomyces albicans adherency rate in the oral cavity of the HIV/AIDS group is higher than that of the healthy control group（P＜0.005）. Conclusion The saliva sIgA content change and the Saccharomyces albicans adherency change in the HIV/AIDS group easily infected by the oral candidiasis are interdependent and their relationship is rather close.