The researches of bone tissue engineering provide new thoughts and methods to repair mass bone defect. So far the main question of restricting the research of bone tissue engineering is the process of osteogenesis by osteoblast hyperplasia migration and the contradiction of its blood-supply. So neovascularization plays a significant role in bone repair. This article reviews the advancements of the neovascularization of bone tissue engineering. Then raise the problems to solve and the prospect of future research.