The development of sedation techniques has always been inextricably linked with the development of dentistry. Today, the most commonly used dental nitrous oxide sedation technique has been proved to be potential harmful to medical staff, thus new technology of dental sedation is needed. The literature of sedation in dentistry in the recent years focused on three main areas: Midazolam sedation, sedation with dexmedetomidine in dentistry and patient controlled sedation with propofol in dentistry. The aim of this review is to summarize the recent literature in this field and state the current sedation technique in dentistry.