Objective The purpose of this experimental study is to explore the effects of estrogen in survival of random flaps. Methods Eighteen female SD rats were divided into three groups randomly, namely the 100 and 300 μg·kg－1 groups, control group. The experimental models of ultra-length-and-width random flap on rats’back were established, and the ones of experimental groups were injected with estrogen at the distal part of the flaps.The microvessel density and survival area of the random flaps in three groups were tested at different time points.Results The MVD and survival area of 100 μg·kg－1 group are better than those of control group and 300 μg·kg－1 group. Conclusion Proper dose of estrogen can promote angiogenesis of random flaps, and improve the survival area of random flaps.
