Allogenic hematopoietic stem cell transplantation（HSCT） is the most effective treatment for malignant hematologic disease, while graft versus host disease（GVHD） is the main complication and leading cause of mortality in patients receiving HSCT. Oral cavity involvement occurs frequently in patients suffering from GVHD, and it may be the primary or even the only site of GVHD. It is essential for oral professionals to be familiar with various oral GVHD. This review discusses the pathogenesis, multifarious clinical manifestation, available evidence for diagnostic, and the progress of treatment in oral GVHD. The management of the oral GVHD seems to be important in the early diagnosis of GVHD.
