Glucose transporter(GLUT)s are a group of non energy dependent transport proteins in mammalians’ cell membrane, which are the main carriers responsible for transporting glucose into cells. Abnormal GLUTs’ expressions have been reported in many human cancers, and the positive staining of GLUTs is closely related to the genesis, development and prognosis of tumor. GLUTs may be used to develop a new method for early diagnosis and treatment of oral squamous cell carcinoma. This article reviews the research progress on relationships of GLUTs and oral squamous cell carcinoma.