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论文摘要

葡萄糖转运蛋白及其与口腔鳞状细胞癌的关系

Glucose transporters and their relationships with oral squamous cell carcinoma

作者:江寰综述 林志勇审校

Author:Jiang Huan, Lin Zhiyong.

收稿日期:2011-02-16          年卷(期)页码:2012,39(3):401-403

期刊名称:国际口腔医学杂志

Journal Name:International Journal of Stomatology

关键字:葡萄糖转运蛋白, 口腔鳞状细胞癌, 预后,

Key words:glucose transporter, oral squamous cell carcinoma, prognosis,

基金项目:

中文摘要

葡萄糖转运蛋白(GLUT)是一组位于哺乳动物细胞膜上的非能量依赖性转运蛋白,是负责将葡萄糖向细胞内转运的主要载体。据报道,GLUT 在多种恶性肿瘤组织中表达异常,且其表达与肿瘤的发生、发展及预后密切相关。GLUT 有可能为口腔鳞状细胞癌的早期诊断及治疗提供一条新思路。本文就GLUT 与口腔鳞状细胞癌的相关性研究进展作一综述。

英文摘要

Glucose transporter(GLUT)s are a group of non energy dependent transport proteins in mammalians’ cell membrane, which are the main carriers responsible for transporting glucose into cells. Abnormal GLUTs’ expressions have been reported in many human cancers, and the positive staining of GLUTs is closely related to the genesis, development and prognosis of tumor. GLUTs may be used to develop a new method for early diagnosis and treatment of oral squamous cell carcinoma. This article reviews the research progress on relationships of GLUTs and oral squamous cell carcinoma.

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