CA125 antigen was detected in 1981. Studies have found that the level of CA125 in the healthy people and benign tumor sufferers is low, but high in malignant tumor sufferers, especially when the tumor grows very fast. This article will summarize the CA125 contents in all kinds of malignant tumor sufferers and discuss the relationships between CA125 levels and the existence of tumor, clinical stage and prognosis, especially concentrating on the studies of CA125 levels and oral cancer.