With the increasing number of orthodontic patients, the rate of enamel demineralization is getting higher and higher. Although orthodontic treatment does not lead to the direct cause of enamel demineralization, but it has an indirect impact on oral ecological environment. For example, the use of orthodontic appliances, increasing number of orthodontic attachments and orthodontic treatment can lead to more numbers of oral microorganisms, hinder patients clean of food residue. Therefore, the enamel demineralization rate and demineralization teeth bit investigation, enamel demineralizing factors and correlation analysis, prevention measures and oral health research progress are reviewed here.