Objective This study was designed to investigate the key points of nursing and clinical cooperation for computer aided design and computer aided manufacturing(CAD/CAM) of zirconia ceramic restoration system and to achieve optimal result of rehabilitation. Methods According to the specificity of CAD/CAM zirconia ceramic restoration system, we summarized the preprosthetic preparations, nursing works during the process, and care procedures after restoration. Results Nurses can communicate with patients more efficiently, and adequate preparations and skilled nursing care can help ease the tension of patients and improve work efficiency. Conclusion Mastering the treatment steps and working in harmony with clinicals are essential to the success of restoration.