Cleft lip and/or palate(CLP) treatment is rapidly improving. Consequently, the psychological condition of patients with orofacial clefts attracts much attention. Research, prevention, and intervention of psychological issues have become an important part of CLP treatment. However, research on this field is limited, and many details of the psychological effects of CLP remain uncertain. This review examines the published scientific research on the psychosocial impact of CLP among children and adults, summarizes the history and present status of CLP, and provides several suggestions and assumptions on the field.