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论文摘要

牙龈卟啉单胞菌菌毛的生物学特性及毒力

Biological characteristics and virulence of Porphyromonas gingivalis fimbriae

作者:王琳,张建钢,肖水清

Author:Wang Lin, Zhang Jiangang, Xiao Shuiqing

收稿日期:2014-11-21          年卷(期)页码:2015,42(5):606-610

期刊名称:国际口腔医学杂志

Journal Name:International Journal of Stomatology

关键字:菌毛,菌毛A,菌毛A基因,免疫反应,

Key words:fimbria,fimbria A,fimbria A gene,immune reaction,

基金项目:

中文摘要

菌毛(Fim)是牙龈卟啉单胞菌的重要致病因子之一,对宿主细胞的黏附发挥着重要作用。Fim是细胞表面的丝状突起,增强了细胞对唾液蛋白、细胞外基质和真核细胞以及同类或其他种属细菌的黏附性并参与生物膜的形成。FimA蛋白是牙龈卟啉单胞菌Fim的主要亚单位,与该菌侵入到牙周组织的上皮细胞及结缔组织内有关,而且还对牙槽骨具有一定的破坏作用。本文主要就Fim蛋白的生物学特性及其毒力等研究进展作一综述。

英文摘要

Fimbriae(Fim), one of the important pathogenic factors of Porphyromonas gingivalis(P.gingivalis), plays an important role in the attachment to host cells. Filamentous protrusions on the surface of the cell increase the attachment to the cell and salivary protein, extracellular matrix, eukaryotic cells, and similar other species of bacteria. These protrusions also participate in the formation of biofilms. FimA protein, the main subunit of the fimbriae of P.gingivalis, is not only related to the invasion into epithelial cells and connective tissues in periodontal tissue but also has a certain destructive effect on the alveolar bone. This paper describes the biological characteristics and virulence of P.gingivalis fimbriae.

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