Human neutrophil peptide(HNP)-1-3 is a natural defense protein that exerts strong fatal or inhibitory effects on bacteria, fungi, viruses, and cancer cells. The expression level of HNP-1-3 in the saliva of children is significantly correlated with their caries risk. Its mass concentration in the saliva directly influences the oral ecological environment of the host. This protein can significantly inhibit majorcariogenic bacteria. HNP-1-3 is an important indicator of caries risk and can be effectively utilized in caries risk prediction in children, especially in those with limited medical resources.
