Objective The purpose of this study was to investigate the present proportional ratio and incidence features of oral-maxillofacial tumors of patients in the Xinjiang Region. Methods The medical data of inpatients with oralmaxillofacial diseases in People’s Hospital of Xinjiang Urgur Autonomous Region from 2008 to 2013 were reviewed and analyzed. Results Benign tumors(36.3%) were the most common among the 2 085 subjects of the study. Vascular tumor was the most common type of benign tumor, followed by facial area lesions, which are common in female patients and the Uyghur people. The prevalence of tumors in female patients showed an increasing trend. Squamous cell carcinoma is the most common type of malignant oral-maxillofacial tumor and is characterized by lesions in the lip region. Furthermore, squamous cell carcinoma is commonly found among Uyghur patients and male patients. The predilection age stage of malignant oral-maxillofacial tumors is decreasing. Conclusion The proportion of oral-maxillofacial tumors among patient in the Xinjiang Region was different from that among patients in the eastern regions. This difference should attract enough attention from surgeons concentrating on clinical work to prevent oral disease.