Objective To explore the effect of psychological intervention on the relief of oral lichen planus(OLP). Methods Two hundred and ten patients with OLP were randomly divided into two groups, 105 patients in the treatment of drug treatment, based on the psychological treatment, as a psychological treatment group; 105 cases of drug treatment, as the control group. Recorded 2 groups of patients psychological scale scores and mucosal damage to score points(including signs and symptoms score) and treatment efficacy respectively in the first option, 2 weeks after treatment, 1 month, 3 months, 6 months and 9 months after the visit. Results The OLP lesion signs and symptoms score of psychological treatment group decreased significantly, and lesions of the OLP healing time was shortened, relieve pain, prolonged remission. The difference between the two groups was statistically significant(P