Objective To investigate the influence of Liuwei Dihuang Pill(LWDHP) treating periodontal during the postmenopausal women. Methods Twenty-seven postmenopausal female patients with moderate to advanced chronic periodontal disease were chosen, and were divided into two groups randomly. Basic treatment group: patients didn’t take any medicine, only accept initial therapy of periodontal. LWDHP treatment group: initial therapy of periodontal with oral took LWDHP 2 months. Collected and detected the concentration of interleukin(IL)-6, estrogen(E2) in gingival crevicular fluid(GCF) before and after treatment. Results A significant decrease was shown in the concentrations of GCF-IL-6 of two groups after therapy compared to before treatment on 2nd month, it had statistically differences(P0.05). Basic treatment group increased the concentrations of GCF-E2 of two groups after therapy compared to before treatment on 2nd month. Basic treatment group had no statistically significant difference(P>0.05), LWDHP treatment group had statistically significant differences(P
