口腔慢性移植物抗宿主病患者唾液T细胞相关细胞因子的表达水平
Salivary T cell cytokine expression in oral chronic graft-versus-host-disease
作者：彭艳1,2 雍翔智1 冯豆豆1,2 曾启新1 梅国城1 陶人川1,2
Author：Peng Yan1,2, Yong Xiangzhi1, Feng Doudou1,2, Zeng Qixin1, Mei Guocheng1, Tao Renchuan1,2
收稿日期：2016-01-02 年卷（期）页码：2016,43(5):524-527
期刊名称：国际口腔医学杂志
Journal Name：International Journal of Stomatology
关键字：造血干细胞移植,口腔慢性移植物抗宿主病,T细胞,
Key words：hematopoietic stem cell transplantation,oral chronic graft-versus-host-disease,T cell,
基金项目：广西自然科学基金（2014GXNSFAA118149）
中文摘要
目的 检测异基因造血干细胞移植后口腔慢性移植物抗宿主病（cGVHD）患者唾液T细胞相关细胞因子的表达水平，了解患者T细胞的免疫状态及其作用机制。方法 移植组纳入确诊为口腔cGVHD患者18例，并对其口腔表征进行评分；对照组纳入健康者18例。收集两组唾液，采用流式液相多重蛋白定量技术检测T细胞相关细胞因子——干扰素（IFN）-γ、白细胞介素（IL）-4、IL-6、IL-10表达水平。结果 移植组中IFN-γ，IL-4水平与对照组无统计学差异；移植组IL-6、IL-10表达量分别为255.04 pg?mL-1和1.49 pg?mL-1，显著高于对照组6.02 pg?mL-1和0.17 pg?mL-1，差异具有统计学意义（P
英文摘要
Objective This study aimed to explore the levels of T-cell cytokines in saliva of patients with oral chronic graft-versus-host-disease(cGVHD) who have undergone hematopoietic stem cell transplantation, as well as understand the T-cell immune status in patients. Methods Eighteen oral cGVHD patients were recruited as the transplantation group, and the scores of oral manifestations were recorded. Furthermore, 18 healthy volunteers were selected as healthy controls. The unstimulated saliva of the two groups was collected, and the concentrations of T-cell cytokines such as interferon(IFN)-γ, interleukin(IL)-4, IL-6, and IL-10 in saliva were detected by cytometric bead array. Results IFN-γ and IL-4 levels in the transplantation group showed no difference from those of healthy controls. By contrast, the levels of IL-6 and IL-10 were significantly higher than those of healthy controls(255.04 pg?mL-1 vs. 6.02 pg?mL-1 and 1.49 pg?mL-1 vs. 0.17 pg?mL-1, respectively; P
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