Studies on mechanotransduction have focused on stomology-related bone biology. In in mechanotransduction, cellular responses to mechanical stress, such as fluid shear stress or matrix deformation in vitro, involve multiple signal pathways, including mitogen-activated protein kinase pathway. This pathway is activated through integrin, calcium channel, and lipid raft under mechanical stress and regulates downstream signal molecules, such as transcription factor core binding factors α1 and activator protein-1. Crosstalks are present between mechanical stress-induced mitogen-activated protein kinase pathway and other receptor pathways(such as estrogen, parathyroid hormone, and 1,25-dihydroxy-cholecalciferol receptor pathways). These crosstalks are important regulatory mechanisms of mechanotransduction.
