WD40-encoding RNA antisense toP53 has three exons:1α, 1β, and 1γ. The exon 1α ofWRAP53 directly overlaps the first exon ofP53 in an antisense way. TheWRAP53 1α transcript could regulate the level ofP53 RNA, and then induce the expression of the P53 protein. The biological behavior of tumor could be regulated by P53 protein. The exon 1β of WRAP53 produces a protein calledWRAP53 protein, which is associated with programmed cell death, cycle regulation, protease degradation and RNA metabolism. WRAP53 protein contacts with various components of telomerase, helps the telomerase to locate in Cajal body(CB) and is an essential factor for CB formation, maintenance and the location of survival motor neuron.WRAP53 has a high expression in tumor cell and clinical tumor sample. The higher the expression ofWRAP53 is, the worse of the prognosis of tumor will be. Silencing theWRAP53 can inhibit the growth of tumor cell. Dyskeratosis congenital is related to the shortage of the length of telomere which is owing to the low expression ofWRAP53.
