The bonding of orthodontic brackets may increase dental plaque adhesion and promote microbial imbalance. This phenomenon subsequently leads to enamel demineralization and periodontal damage. Commonly used methods cannot control dental plaque, but antimicrobial modification on the surface of orthodontic brackets can eliminate this defect. Materials for antimicrobial modification include TiO2, Ag, and polytetrafluoroethylene, which can reduce plaque biofilmformation. Commonly used coating methods include physical vapor deposition, sol-gel, liquid phase deposition, electrochemical process, and anodic oxidation. Antibacterial coating exhibits favorable biocompatibility and prevents oral mucosal irritation, short-term systemic toxicity, and genetic toxicity. Thus, this method meets the application requirements of oral biological materials.