原发性三叉神经痛与单纯疱疹病毒感染的相关性研究进展
The progress of relationship between primary trigeminal neuralgia and herpes simplex virus infection
作者：许鹏,陈传俊
Author：Xu Peng, Chen Chuanjun
收稿日期：2015-07-12 年卷（期）页码：2016,43(2):220-222
期刊名称：国际口腔医学杂志
Journal Name：International Journal of Stomatology
关键字：原发性三叉神经痛,单纯疱疹病毒,神经节,脱髓鞘,原发性三叉神经痛,单纯疱疹病毒,神经节,脱髓鞘,
Key words：primary trigeminal neuralgia,herpes simplex virus,ganglion,demyelination,primary trigeminal neuralgia,herpes simplex virus,ganglion,demyelination,
基金项目：国家自然科学基金（81550037）
中文摘要
原发性三叉神经痛（PTN）的病因和发病机制至今仍不清楚，近来越来愈多的研究揭示其与单纯疱疹病毒（HSV）的潜伏有关。PTN患者的三叉神经节和神经根有明显的脱髓鞘变，而脱髓鞘病变是PTN的主要病理基础。HSV依赖其嗜神经特性感染三叉神经半月节并长期潜伏，在机体免疫低下时激活，造成对三叉神经的慢性炎症性刺激，导致三叉神经脱髓鞘病变进而引发PTN。诠释PTN的病因和发病机制，对于揭开三叉神经痛之谜，创建并运用有针对性的治疗方法具有重要的临床意义。
英文摘要
The etiology and pathogenesis of primary trigeminal neuralgia(PTN) is unclear. Recent research reveals that PTN is related to the latency of herpes simplex virus(HSV). The trigeminal ganglia and nerve root in patients with PTN present obvious demyelination changes, which are the main pathological bases of PTN. Depending on its neurotropism, HSV infects the semilunar ganglion of trigeminal nerve and becomes latent for a long time. HSV is activated again when the body immunity is low, causing chronic inflammation of the trigeminal nerve and leading to demyelinating lesions and PTN. Interpretation of the etiology and pathogenesis of PTN would be important clinical significance for revealing the mystery of trigeminal neuralgia and creation and use of targeted therapy.
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