Sinusoidal obstruction syndrome/veno-occlusive disease(SOS/VOD) is an early complication after hematopoietic stem cell transplantation(HSCT). SOS/VOD in children is different from adults in terms of morbidity, clinical manifestations, diagnostic criteria and treatment. The new diagnostic criteria and severity grading standards established on the basis of recent decades of research provide theoretical basis for the prevention, diagnosis and treatment of children with SOS/VOD. Further discovery of more serological and molecular markers is conducive to the early diagnosis and treatment of SOS/VOD in children. Drug treatment represented by defibrillin can improve the survival rate of children with SOS/VOD. This article reviews on the new progress of children with SOS/VOD after HSCT in recent years from the aspects of pathogenesis and high risk factors, clinical manifestations, assisted examination, diagnosis, differential diagnosis and treatments.
