Erythrocytes are important components of the blood. Erythrocytes are mainly produced by the bone marrow in healthy adults and maintain normal physiological activities by participating in the delivery of O2and CO2. The progress of erythropoiesis involves complex regulation network, in which transcriptional regulation is crucial. Many transcription factors are involved in the progress of commitment of erythroid lineage, differentiation and maturity of erythrocytes and synthesis of hemoglobin (Hb). This article will review the progress of transcriptional regulation in erythropoiesis, mainly focus on GATA transcription factors, Kruppel-like transcription factors (KLF) and forkhead transcription factors.
