Parvovirus (PV) B19 is a member of the erythrovirus genus, the familyParvoviridae.It is a single-stranded DNA virus with a high rate of human infection.PVB19 infection can involve multiple organs and tissues, and participate in the occurrence and development of certain diseases.The clinical manifestations of PVB19 infection are diverse, which can cause various complications such as myocarditis, pneumonia, hepatitis and glomerulonephritis. For people with normal immune function, PVB19 infection could be asymptomatic or mild. However, for special populations with immune deficiencies such as patients after solid organ transplantation (SOT) and hematopoietic stem cell transplantation (HSCT), it may lead to dysfunction of the transplanted organ or gtaft, even transplant failure.This article explains the clinical manifestations in patients with PVB19 infection through PVB19 virus biology and its infection immune mechanisms, common clinical manifestations of PVB19 infection, PVB19 infection after transplantation, and the diagnosis and treatment of PVB19 infection, in order to re-understand PVB19 infection from different perspectives such as biology and infection immunity, and provide a basis for the diagnosis and treatment of PVB19 infection after transplantation.
