期刊导航

论文摘要

红细胞生成的转录调控机制研究进展

Research progress on transcriptional regulation in erythropoiesis

作者:

Author:

收稿日期:2020-01-07          年卷(期)页码:2020,43(05):457-460

期刊名称:国际输血及血液学杂志

Journal Name:International Journal of Blood Transfusion and Hematology

关键字:红细胞生成,转录因子,GATA转录因子类,Kruppel样转录因子类,叉头转录因子类

Key words:Erythropoiesis|Transcription factors|GATA transcription factors|Kruppel-like transcription factors|Forkhead transcription factors

基金项目:

中文摘要

红细胞是重要的血液组成成分,其在健康成年人体内主要由骨髓产生,通过参与O2和CO2运输,维持机体正常生理活动。红细胞生成涉及复杂的调控网络,其中转录调控对于红细胞生成至关重要,对红系谱系确立、红细胞分化、成熟,以及血红蛋白(Hb)生成等,均发挥重要作用。此过程涉及GATA转录因子、Kruppel样转录因子(KLF)及叉头转录因子等多种重要转录因子。笔者拟就上述转录因子在红细胞生成中的调控机制的研究进展进行综述。

英文摘要

Erythrocytes are important components of the blood. Erythrocytes are mainly produced by the bone marrow in healthy adults and maintain normal physiological activities by participating in the delivery of O2and CO2. The progress of erythropoiesis involves complex regulation network, in which transcriptional regulation is crucial. Many transcription factors are involved in the progress of commitment of erythroid lineage, differentiation and maturity of erythrocytes and synthesis of hemoglobin (Hb). This article will review the progress of transcriptional regulation in erythropoiesis, mainly focus on GATA transcription factors, Kruppel-like transcription factors (KLF) and forkhead transcription factors.

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