ObjectiveTo determine the effect of tranexamic acid (TXA) after cardiopulmonary bypass (CPB) on the outcomes of cardiac surgery patients.MethodsThis retrospective study included adult patients (≥ 18 years old) who underwent elective valve replace surgery and/or coronary artery bypass surgery (CABG) with CPB from July 1, 2011 to December 31, 2016 in West China Hospital of Sichuan University. The patients were divided into TXA group (n=2 062), who received TXA after CPB, and the control group (n=4 236), who did not receive any TXA at all. The differences in postoperative complications such as death, excessive bleeding, ischemic event and bleeding related event, ICU and hospitality duration of the two groups were analyzed. Logistic regression analysis was performed to examine the effects of TXA on the outcomes of the patients.ResultsThe rate of excessive bleeding and the median chest tube drainage of TXA group were less than those of control group (PP>0.05). Multivariable regression analysis showed TXA after CPB was associated with the reduced risks of excessive bleeding[odds ratio (OR):0.55, 95%confidence interval (CI):0.49-0.62,POR:0.55, 95%CI:0.30-0.98,P=0.044), but was not associated with ischemic event and bleeding related event.ConclusionTXA after CPB following cardiac surgery could reduce the risk of excessive bleeding and death without increase of ischemic event.
